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Testosterone Undecanoate (Andriol)

Andriol is a unique oral testosterone product, developed by the international drug firm Organon. Drugs administered orally generally enter the blood stream through the liver. When a steroid compound is given this way without some form of structural protection, it will be quickly broken down during the “first pass”. This process leaves very littl...

Andriol is a unique oral testosterone product, developed by the international drug firm Organon. Drugs administered orally generally enter the blood stream through the liver. When a steroid compound is given this way without some form of structural protection, it will be quickly broken down during the “first pass”. This process leaves very little steroid intact, basically deactivating the drug. Adding a methyl group (c-17 AA) to the structure is one way to protect it from this process, however stress is also placed on the liver as a result.

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